Publicación:
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica

dc.contributor.advisorJiménez Forero, Javier
dc.contributor.advisorPineda Insuasti, Julio Amilcar
dc.contributor.authorDuarte Trujillo, Astrid Stefanía
dc.contributor.authorGonzález Trujillo, Camila Alejandra
dc.date.accessioned2023-07-14T14:54:35Z
dc.date.available2023-07-14T14:54:35Z
dc.date.issued2018
dc.descriptionIncluye figuras y tablas.spa
dc.description.abstractLa orellana (Pleurotus ostreatus) es un hongo nutracéutico cuya acción farmacológica ha sido ampliamente reportada en la literatura. La maceración es un método sencillo y económico de extracción de las sustancias bioactivas del hongo, que no pone en riesgo la biodisponibilidad, pero que presenta baja eficiencia de extracción. En este contexto, el objetivo de este trabajo es evaluar el proceso de extracción de sustancias bioactivas de Orellana por maceración dinámica, para determinar qué tratamiento permite la máxima eficiencia de extracción total y por componentes, analizando a su vez la influencia de los factores de operación.spa
dc.description.abstractOyster mushroom (Pleurotus ostreatus) is a nutraceutical fungus whose pharmacological action has been widely reported in the literature. Maceration is a simple and economical method of extracting the bioactive substances from the fungus, which does not jeopardize bioavailability, but which has low extraction efficiency. In this context, the objective of this work is to evaluate the extraction process of bioactive substances of oyster mushroom by dynamic maceration, to determine which treatment allows the maximum total and specific efficiency, analyzing both the influence of the operating factors.eng
dc.description.degreelevelPregradospa
dc.description.degreenameIngeniero(a) Agroindustrialspa
dc.description.programIngeniería Agroindustrialspa
dc.description.tableofcontentsResumen. -- Introducción. -- Objetivos. -- General: -- Específicos: -- Marco teórico y estado del arte. -- Marco teórico. -- Los nutracéuticos. -- Los hongos comestibles como nutracéuticos. -- Las orellanas (pleurotus spp.). -- Sustancias bioactivas de pleurotus ostreatus. -- Los extractos. -- Extractos de orellana. -- Preparación de extractos de orellana por maceración dinámica. -- Eficiencia de extracción. -- Parámetros que afectan la extracción de sustancias bioactivas. -- Estado del arte. -- Metodología. -- Determinación de parámetros de operación. -- Diseño experimental. -- Microorganismos. -- Preparación del material biológico. -- Maceración dinámica. -- Cálculo de la eficiencia de extracción. -- Cuantificación de sustancias bioactivas. -- Carbohidratos totales. -- Azúcares reductores. -- Polisacáridos totales. -- Polifenoles. -- Proteínas. -- Betaglucanos. -- Tratamiento estadístico. -- Resultados y discusión de resultados. -- Evaluación del proceso de extracción en general. -- Análisis del tamaño de partícula. -- Monitoreo de la temperatura. -- Evaluación de eficiencia de extracción. -- Evaluación del proceso de extracción por sustancia bioactiva en particular. -- Cuantificación del contenido de sustancias bioactivas. -- Evaluación de la extracción de carbohidratos totales. -- Evaluación de la extracción de azucares reductores. -- Evaluación de la extracción de polisacáridos totales. -- Evaluación de la extracción de polifenoles totales. -- Evaluación de la extracción de proteínas totales. -- Evaluación de la extracción de betaglucanos. -- Conclusiones. -- Referencias. -- Anexos.spa
dc.format.extent166 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationDuarte Trujillo, Astrid S., & González Trujillo, Camila A. (2018). Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica [Trabajo de grado, Universidad de los Llanos]. Repositorio digital Universidad de los Llanos.spa
dc.identifier.instnameUniversidad de los Llanosspa
dc.identifier.reponameRepositorio digital Universidad de los Llanosspa
dc.identifier.repourlhttps://repositorio.unillanos.edu.co/spa
dc.identifier.urihttps://repositorio.unillanos.edu.co/handle/001/2939
dc.language.isospaspa
dc.publisherUniversidad de los Llanosspa
dc.publisher.facultyFacultad de Ciencias Agropecuarias y Recursos Naturalesspa
dc.publisher.placeVillavicenciospa
dc.relation.indexedN/Aspa
dc.relation.referencesACEVEDO, Adolfo y LINARES, Martha. El enfoque y rol del ingeniero industrial para la gestión y decisión en el mundo de las organizaciones. En: Industrial data. 2012. Vol. 15, no. 1, p. 13. Disponible en: http://www.redalyc.org/pdf/816/81624969002.pdfspa
dc.relation.referencesAGRICULTURAL MARKETING RESOURCE CENTER (AMRC). Mushrooms profile. 2014. Recuperado a partir de http://www.agmrc.org/commodities-products/specialtycrops/mushrooms-profile/spa
dc.relation.referencesALAM, Nuhu et al. Antioxidant Activities and Tyrosinase Inhibitory Effects of Different Extracts from Pleurotus ostreatus Fruiting Bodies. En: Mycobiology. 2010, vol. 38, no. 4, p. 295-301. Disponible en: https://doi.org/10.4489/MYCO.2010.38.4.295spa
dc.relation.referencesALBERTS, J. F., et al. Degradation of aflatoxin B1 by fungal laccase enzymes. En: International Journal of Food Microbiology. 2009, vol. 135, no. 1, p. 47–52. Disponible en: https://doi.org/10.1016/j.ijfoodmicro.2009.07.022spa
dc.relation.referencesALBUQUERQUE, Bianca R, et al. Catechin-based extract optimization obtained from Arbutus unedo L. fruits using maceration/microwave/ultrasound extraction techniques. En: Industrial Crops and Products. 2017, Vol. 95, p. 404–415. Disponible en: https://doi.org/10.1016/j.indcrop.2016.10.050spa
dc.relation.referencesAMIRULLAH, Nur Amalina; ZAINAL ABIDIN, Nurhayati y ABDULLAH, Noorlidah. The potential applications of mushrooms against some facets of atherosclerosis: A review. En: Food Research International. 2018, vol. 105, p. 517–536. Disponible en: https://doi.org/10.1016/j.foodres.2017.11.023spa
dc.relation.referencesANSCOMBE, Jonathan, et al. Nutraceuticals: The front line of the battle for consumer health [en línea]. 2014. Disponible en: https://www.atkearney.comspa
dc.relation.referencesARGENTINA. COMISIÓN PERMANENTE DE LA FARMACOPEA ARGENTINA. Farmacopea Argentina. 7 ed. Buenos Aires: ANMAT, 1996. 2745 p. ISBN 9567419175 Disponible en: http://www.anmat.gov.ar/webanmat/fna/pfds/Farmacopea_Argentina_2013_Ed.7.pdfspa
dc.relation.referencesASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS [AOAC]. Official methods of analysis of the Association of Official Analytical Chemists. 15th ed. Washington, DC: AOAC; 1990.spa
dc.relation.referencesÁVILA, Ramona, et al. Contenido de azúcares totales, reductores y no reductores en Agave cocui Trelease. En: Multiciencias. 2012, vol. 12, no. 2, p. 129–135. Disponible en: https://doi.org/10.5897/AJB11.3143spa
dc.relation.referencesAZMIR, J., et al. Techniques for extraction of bioactive compounds from plant materials: A review. En: Journal of Food Engineering. 2013, vol. 117, no. 4, p. 426–436. Disponible en: https://doi.org/10.1016/j.jfoodeng.2013.01.014spa
dc.relation.referencesBAGGIO, Cristiane Hatsuko, et al. Antinociception of β-D-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition. En: International journal of biological macromolecules. 2012, vol. 50, no. 3, p. 872–877. Disponible en: https://doi.org/10.1016/j.ijbiomac.2011.10.023spa
dc.relation.referencesBANO, Zakia y RAJARATHNAM, S. Pleurotus mushrooms. Part II, nutritional value, postharvest physiology, preservation and role as human food. En: CRC Critical Food Science and Nutrition. 1988, vol. 27, no. 2, p. 87-158. Disponible en: http://dx.doi.org/10.1080/10408398809527480spa
dc.relation.referencesBERGENDIOVA, Katarina; TIBENSKA, Elena y MAJTAN, Jurak. Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. En: European Journal of Applied Physiology. 2011, vol. 111, no. 9, p. 2033–2040. Disponible en: https://doi.org/10.1007/s00421-011-1837-zspa
dc.relation.referencesBERNAL RODRÍGUEZ, Carlos Alfonso. Contribución al estudio farmacotécnico del extracto estandarizado de frutos de Physalis peruviana L. con miras a la obtención de un producto fitoterapéutico. Tesis de Magíster en Ciencias Farmacéuticas. Bogotá D.C.: Universidad Nacional de Colombia. Facultad de farmacia, 2012. p. 5. Disponible en: http://www.bdigital.unal.edu.co/9016/1/192546.2012.pdfspa
dc.relation.referencesBERNHOFT, Aksel. Bioactive Compounds in Plants: Benefits and Risks for Man and Animals. En: FORLAG, Novus. Proceedings from a Symposium Held in Norwegian Academy of Science and Letters. 13 - 14 November, 2008. Oslo: Det Norske Videnskaps-Akademi. 2010, p. 11–17. ISBN 978-82-7099-583-7.spa
dc.relation.referencesBHATTACHARYA, M.; SRIVASTAV, P. P. y MISHRA, H. N. Optimization of process variables for supercritical fluid extraction of ergothioneine and polyphenols from Pleurotus ostreatus and correlation to free-radical scavenging activity. En: The Journal of Supercritical Fluids. 2014, vol. 95, p. 51-59. Disponible en: https://doi.org/10.1016/j.supflu.2014.07.031spa
dc.relation.referencesBONATTI, Mariane, et al. Evaluation of Pleurotus ostreatus and Pleurotus sajor-caju nutritional characteristics when cultivated in different lignocellulosic wastes. En: Food Chemistry. 2004, vol. 88, no. 3, p. 425–428. Disponible en: https://doi.org/10.1016/j.foodchem.2004.01.050spa
dc.relation.referencesBRADFORD, Marion M. A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding. En: Analytical Biochemistry. 1976, vol. 72, p. 248–254. Disponible en: http://hoffman.cm.utexas.edu/courses/bradford_assay.pdfspa
dc.relation.referencesBRAVO, Karent E., et al. Desarrollo de un método para la extracción de polifenol oxidasa de uchuva (Physalis peruviana l.) y aislamiento por sistemas bifásicos acuosos. En: Vitae, vol. 18, no. 2, p. 124–132. Disponible en http://www.scielo.org.co/pdf/vitae/v18n2/v18n2a03.pdfspa
dc.relation.referencesBRECHTEL, Rolf; WÄTZIG, Hermann y RÜDIGER, Harold. The lectin from the mushroom Pleurotus ostreatus: A phosphatase-activating protein that is closely associated with an α-galactosidase activity: A part of this paper has been presented as a preliminary report at the 17th interlec. Meeting 1997 in Würzburg, Germany. En: Plant Science. 2001, vol. 160, no. 5, p. 1025–1033. Disponible en: https://doi.org/10.1016/S01689452(01)00349-1spa
dc.relation.referencesCANADÁ. AGRICULTURE AND AGRI-FOOD. Consumer trends: functional foods. Market Analysis Report. El Ministerio: December, 2009. p. 4. Disponible en: https://www.gov.mb.ca/agriculture/market-prices-and-statistics/food-and-value-addedagriculture-statistics/pubs/consumer_trends_functional_foods_en.pdfspa
dc.relation.referencesCARDONA URREA, Luis Fernando. Anotaciones acerca de la bromatología y el cultivo del hongo comestible Pleurotus ostreatus. En: Crónica Forestal y del Medio Ambiente. 2001, vol. 16, p. 99–119.spa
dc.relation.referencesCHANG, Shu-Ting y MILES, Philip G. Mushrooms: Cultivation, nutritional value, medicinal effect, and environmental impact. 2. ed. Florida: CRC Press, 2004. p. 8. ISBN 0-84931043-1.spa
dc.relation.referencesCHAUHAN, Baby, et al. Current concepts and prospects of herbal nutraceutical: A review. En: J Adv Pharm Technol Res. 2013, vol. 4, no. 1, p. 4–8. Disponible en: https://doi.org/10.4103/2231-4040.107494spa
dc.relation.referencesCHEN, Lei, et al. Cell wall structure of mushroom sclerotium (Pleurotus tuber regium): Part 1. Fractionation and characterization of soluble cell wall polysaccharides. En: Food Hydrocolloids. 2014, vol. 36, p. 189–195. Disponible en: https://doi.org/10.1016/j.foodhyd.2013.09.023spa
dc.relation.referencesCHEN, Shin Yu, et al. Contents of lovastatin, γ-aminobutyric acid and ergothioneine in mushroom fruiting bodies and mycelia. En: LWT - Food Science and Technology. 2012, vol. 47, no. 2, p. 274–278. Disponible en: https://doi.org/10.1016/j.lwt.2012.01.019spa
dc.relation.referencesCHITIVA JARAMILLO, Adriana, et al. Contribución al estudio de microhongos filamentosos en los ecosistemas Páramo de Guasca y El Tablazo. Estudio preliminar de mohos de páramos colombianos. Bogotá D.C.: Universidad Pontificia Bolivariana, 2007. p. 3. Disponible en: http://www.javeriana.edu.co/gifuj/hongos_%20ecosistemas_%20paramo.pdfspa
dc.relation.referencesCHILDS, Nancy M. Obesity policy: Opportunities for Funcional Food Market Growth. En: Handbook of Nutraceuticals and Functional Foods. 2 ed. Boca Raton, Florida: Robert E. C. Wildman, 2007. p. 1–22. ISBN: 978-1-4200-0618-6. Disponible en: https://doi.org/10.1201/9781420006186spa
dc.relation.referencesCHOBOT, Vladimir, et al. Ergosta-4,6,8,22-tetraen-3-one from the edible fungus, Pleurotus ostreatus (oyster fungus). En: Nutrition. 1997, vol. 45, no. 8, p. 1669–1671. Disponible en: https://doi.org/10.1016/S0031-9422(97)00249-5spa
dc.relation.referencesCHOI, Jae Ho et al. Topical application of Pleurotus eryngii extracts inhibits 2,4dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by the regulation of Th1/Th2 balance. En: Food and Chemical Toxicology. 2013, vol. 53, p. 38–45. Disponible en: https://doi.org/10.1016/j.fct.2012.11.025spa
dc.relation.referencesCHOU, Youn-Min; POLANSKY, Alan M y MASON, Robert L. Transforming non-normal data to normality in statistical process control. En: Journal of Quality Technology. 1998, vol. 30, no. 2, p. 133–141. Disponible en: https://goo.gl/zzmnWRspa
dc.relation.referencesCILERDZIC, Jasmina, et al. Antioxidant and Antifungal Potential of Pleurotus ostreatus and Agrocybe cylindracea Basidiocarps and Mycelia. En: Current Pharmaceutical Biotechnology. 2015, vol. 17, no. 2, p. 179–186. Disponible en: http://www.ingentaconnect.com/content/ben/cpb/2015/00000016/00000002/art00010spa
dc.relation.referencesCOLOMBIA. DEPARTAMENTO NACIONAL DE PLANEACIÓN (DNP). Bases del Plan Nacional de Desarrollo 2014-2018. Bogotá D.C.: El departamento, 2014. 783 p. Disponible en: https://colaboracion.dnp.gov.co/cdt/prensa/bases%20plan%20nacional%20de%20des arrollo%202014-2018.pdfspa
dc.relation.referencesCOLOMBIA. MINISTERIO DE LA PROTECCIÓN SOCIAL. Decreto Número 2266 (14, julio, 2004). Por el cual se reglamentan los regímenes de registros sanitarios, y de vigilancia y control sanitario y publicidad de los productos fitoterapéuticos. Bogotá D.C.: El Ministerio, 2004. p. 3. Disponible en: http://biblioteca.saludcapital.gov.co/img_upload/03d591f205ab80e521292987c313699 c/decreto_2266_2004.pdfspa
dc.relation.referencesCONRAD, Fritz y RÜDIGER, Harold. The lectin from Pleurotus ostreatus: Purification, characterization and interaction with a phosphatase. En: Phytochemistry. 1994, vol. 36, no. 2, p. 277–283. Disponible en: https://doi.org/10.1016/S0031-9422(00)97061-4spa
dc.relation.referencesĆUJIĆ, Nada, et al. Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique. En: Food Chemistry. 2016, vol. 194, p. 135–142. Disponible en: https://doi.org/10.1016/j.foodchem.2015.08.008spa
dc.relation.referencesDALONSO, Nicole, et al. Characterization and antineoplasic effect of extracts obtained from Pleurotus sajor-caju fruiting bodies. En: Applied Biochemistry and Biotechnology. 2010, vol. 160, no. 8, p. 2265 – 2274. Disponible en: https://doi.org/10.1007/s12010009-8678-9spa
dc.relation.referencesDEEPALAKSHMI, Krishnamoorthy y MIRUNALINI, Sankaran. Efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P. kumm. on 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats. En: New Horizons in Translational Medicine. 2016, vol. 3, no. 2, p. 73–82. Disponible en: https://doi.org/10.1016/j.nhtm.2016.06.002spa
dc.relation.referencesDEVI, K. Sanjana P, et al. Characterization and lectin microarray of an immunomodulatory heteroglucan from Pleurotus ostreatus mycelia. En: Carbohydrate Polymers. 2013, vol. 94, no. 2, p. 857–865. Disponible en: https://doi.org/10.1016/j.carbpol.2013.02.017spa
dc.relation.referencesDEVI, K. Sanjana P, et al. Immune augmentation and Dalton’s Lymphoma tumor inhibition by glucans/glycans isolated from the mycelia and fruit body of Pleurotus ostreatus. En: International Immunopharmacology. 2015, vol. 25, no. 1, p. 207–217. Disponible en: https://doi.org/10.1016/j.intimp.2015.01.026spa
dc.relation.referencesDIEM, Konrad. Tablas Cientificas: Documenta Geigy. Basilea: J.R. Geigy S. A., 1965. p. 320-321spa
dc.relation.referencesDUBOIS, Michel, et al. Colorimetric method for determination of sugars and related substances. En: Analytical Chemistry. 1956, vol. 28, no. 3, p. 350–356. Disponible en: https://doi.org/10.1021/ac60111a017spa
dc.relation.referencesELISASHVILI, Vladimir, et al. Use of Pleurotus dryinus for lignocellulolytic enzymes production in submerged fermentation of mandarin peels and tree leaves. En: Enzyme and Microbial Technology. 2006, vol. 38, no.7, p. 998–1004. Disponible en: https://doi.org/10.1016/j.enzmictec.2005.08.033spa
dc.relation.referencesEL-FAKHARANY, Esmail M., et al. Oyster Mushroom Laccase Inhibits Hepatitis C Virus Entry into Periph- eral Blood Cells and Hepatoma Cells. En: Protein & Peptide Letters. 2010, vol. 17, no. 1, p. 1031–1039. Disponible en: https://doi.org/10.2174/092986610791498948spa
dc.relation.referencesFACCHINI, Jean Mary, et al. Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180. En: International Journal of Biological Macromolecules. 2014, vol. 68, p. 72–77. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2014.04.033spa
dc.relation.referencesFINIMUNDY, Tiane C., et al. Aqueous extracts of Lentinula edodes and Pleurotus sajorcaju exhibit high antioxidant capability and promising in vitro antitumor activity. En: Nutr. Res. 2013, vol. 33, p. 76–84. Disponible en: https://doi.org/10.1016/j.nutres.2012.11.005spa
dc.relation.referencesFLORES, Maria Victoria, VOGET, C. y ERTOLA, J. Permeabilization of yeast cells (Kluyveromyces lactis) with organic solvents. En: Enzyme and Microbial Technology. 1994, vol. 16, no. 4, p. 340–346. Disponible en: https://doi.org/10.1016/01410229(94)90177-5spa
dc.relation.referencesFONTES VIEIRA, Patrícia A. et al. Antioxidant activities, total phenolics and metal contents in Pleurotus ostreatus mushrooms enriched with iron, zinc or lithium. En: LWT - Food Science and Technology. 2013, vol. 54, no. 2, p. 421–425. Disponible en: https://doi.org/10.1016/j.lwt.2013.06.016spa
dc.relation.referencesFOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS (FAO). Statistics. [en línea]. Disponible en: http://faostat3.fao.org/home/Espa
dc.relation.referencesAO, Wenjuan, et al. Mushroom lectin enhanced immunogenicity of HBV DNA vaccine in C57BL/6 and HBsAg-transgenic mice. En: Vaccine. 2013, vol. 31, no. 18, p. 2273– 2280. Disponible en: https://doi.org/10.1016/j.vaccine.2013.02.062spa
dc.relation.referencesGASECKA, Monika, et al. The effect of selenium on phenolics and flavonoids in selected edible white rot fungi. En: LWT - Food Science and Technology. 2015, vol. 63, no, 1, p. 726–731. Disponible en: https://doi.org/10.1016/j.lwt.2015.03.046spa
dc.relation.referencesGIL RAMÍREZ, Alicia, et al. Mushrooms do not contain flavonoids. En: Journal of Functional Foods. 2016, vol. 25, p. 1–13. Disponible en: https://doi.org/10.1016/j.jff.2016.05.005spa
dc.relation.referencesGIL RAMÍREZ, Alicia, et al. Screening of edible mushrooms and extraction by pressurized water (PWE) of 3-hydroxy-3-methyl-glutaryl CoA reductase inhibitors. En: Journal of Functional Foods. 2012, vol. 5, p. 244-250. Disponible en: https://doi.org/10.1016/j.jff.2012.10.013spa
dc.relation.referencesGOMES CORRÊA, Rúbia Carvalho, et al. Biotechnological, nutritional and therapeutic uses of Pleurotus spp. (Oyster mushroom) related with its chemical composition: A review on the past decade findings. En: Trends in Food Science & Technology. 2016, vol. 50, p. 103–117. Disponible en: https://doi.org/10.1016/j.tifs.2016.01.012spa
dc.relation.referencesGRIFFIN, Roger D. Principles of Hazardous Materials Management. 2. ed. Boca Raton: CRC Press, 2009. P. 216.ISBN 9781420089714.spa
dc.relation.referencesGULLÓN, Beatriz, et al. Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability. En: Trends in Food Science & Technology. 2017, no. 67. p. 220-235. Disponible en: https://doi.org/10.1016/j.tifs.2017.07.008spa
dc.relation.referencesGUNAWARDENA, Dhanushka, et al. Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages. En: Food Chemistry. 2014, vol. 148, p. 92–96. Disponible en: https://doi.org/10.1016/j.foodchem.2013.10.015spa
dc.relation.referencesHAPSARI, Riani; ELYA, Berna y AMIN, Juheini. Formulation and evaluation of antioxidant and tyrosinase inhibitory effect from gel containing the 70% ethanolic Pleurotus ostreatus extract. En: Int. J. Med. Arom. Plants. 2012, vol. 2, no. 1, p. 135–140. Disponible en: https://goo.gl/b3nSXEspa
dc.relation.referencesHASHIM, Shima N. N. S., et al. Recovery of ergosterol from the medicinal mushroom, Ganoderma tsugae var. Janniae, with a molecularly imprinted polymer derived from a cleavable monomer-template composite. En: Journal of Chromatography A. 2016, vol. 1468, p. 1–9. Disponible en: https://doi.org/10.1016/j.chroma.2016.09.004spa
dc.relation.referencesHATHCOCK, John N., & SHAO, Andrew. Risk assessment for coenzyme Q10 (Ubiquinone). En: Regulatory Toxicology and Pharmacology. 2006, vol. 45, no. 3, p. 282–288. Disponible en: https://doi.org/10.1016/j.yrtph.2006.05.006spa
dc.relation.referencesHU, Shu Hui et al. Antihyperlipidemic and Antioxidant Effects of Extracts from Pleurotus citrinopileatus. En: Journal of Agricultural and Food Chemistry. 2006, vol. 54, no. 6, p. 2103–2110. Disponible en: https://doi.org/10.1021/jf052890dspa
dc.relation.referencesHUANG, Shih Jeng; LIN, Chun Ping y TSAI, Shu Yao. Vitamin D2 content and antioxidant properties of fruit body and mycelia of edible mushrooms by UV-B irradiation. En: Journal of Food Composition and Analysis. 2015, vol. 42, p. 38–45. Disponible en: https://doi.org/10.1016/j.jfca.2015.02.005spa
dc.relation.referencesKEWUCHI, J. C., et al. Moderation of hematological and plasma biochemical indices of sub-chronic salt-loaded rats by aqueous extract of the sclerotia of Pleurotus tuberregium (Fr) Sing’s: Implications for the reduction of cardiovascular risk. En: Journal of Ethnopharmacology. 2013, vol. 150, no. 2, p. 466–476. Disponible en: https://doi.org/10.1016/j.jep.2013.09.002spa
dc.relation.referencesINSTITUTO COLOMBIANO DE NORMALIZACIÓN Y CERTIFICACIÓN. Sistemas de Gestión de la Calidad: fundamentos y vocabulario. NTC-ISO 9000. Bogotá D.C.: El instituto, 2005. p. 10. Disponible en: https://tienda.icontec.org/wp- content/uploads/pdfs/NTC-ISO9000-2015.pdfspa
dc.relation.referencesWALOKUN, Bamidele, et al. Comparative phytochemical evaluation, antimicrobial antioxidant properties of Pleurotus ostreatus. African Journal of Biotechnology. 2007, vol 6, no. 15, p. 1732-1739. Disponible en: http://www.ajol.info/index.php/ajblarticle/download/57767/46134spa
dc.relation.referencesJAYAKUMAR, T., et al. Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain. En: ChemicoBiological Interactions. 2008, vol. 176, no. 2–3, p. 108–120. Disponible en: https://doi.org/10.1016/j.cbi.2008.08.006spa
dc.relation.referencesJESENAK, Milos, et al. Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. En: Phytotherapy Research. 2014, vol. 28, no. 3, p. 471–474. Disponible en: https://doi.org/10.1002/ptr.5020spa
dc.relation.referencesJESENAK, Milos, et al. Immunomodulatory effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. En: International Immunopharmacology. 2013, vol. 15, no. 2, p. 395-399. Disponible en: https://doi.org/10.1016/j.intimp.2012.11.020spa
dc.relation.referencesJIAO, Fengping, et al. Processing optimization and anti-oxidative activity of enzymatic extractable polysaccharides from Pleurotus djamor. En: International Journal of Biological Macromolecules. 2017, vol. 98, p. 469–478. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2017.01.126spa
dc.relation.referencesJOVANOVIĆ, Aleksandra A., et al. Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques. En: Separation and Purification Technology. 2017, vol. 179, p. 369–380. Disponible en: https://doi.org/10.1016/j.seppur.2017.01.055spa
dc.relation.referencesKAKON, A. J.; CHOUDHURY, Md Bazlul Karim y SAHA, Shusmita. Mushroom in an ideal food supplement. En: Journal of Dhaka National Medical College & Hospital. 2012, vol. 18, p. 58-62. Disponible en: http://dx.doi.org/10.3329/jdnmch.v18i1.12243spa
dc.relation.referencesKALARAS, Michael D., et al. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. En: Food Chemistry. 2017, vol. 233, p. 429–433. Disponible en: https://doi.org/10.1016/j.foodchem.2017.04.109spa
dc.relation.referencesKAWAGISHI, Hirokazu, et al. A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance. En: Biochimica et Biophysica Acta - General Subjects. 2000, vol. 1474, no. 3, p. 299–308. Disponible en: https://doi.org/10.1016/S0304-4165(00)00027-1spa
dc.relation.referencesKHAN, Asma Ashraf, et al. Structural, rheological, antioxidant, and functional properties of β–glucan extracted from edible mushrooms Agaricus bisporus, Pleurotus ostreatus and Coprinus attrimentarius. En: Bioactive Carbohydrates and Dietary Fibre. 2017, vol. 11, p. 67–74. Disponible en: https://doi.org/10.1016/J.BCDF.2017.07.006spa
dc.relation.referencesKHARB, Simmi y SINGH, Veena. Nutriceuticals in health and disease prevention. En: Indian Journal of Chemical Biochemistry. 2004, vol. 59, no. 1, p. 50-53. Disponible en: https://doi.org/10.1007/BF02872389spa
dc.relation.referencesKHATUN, Selima, et al. Nutritional qualities and antioxidant activity of three edible oyster mushrooms (Pleurotus spp.). En: NJAS - Wageningen J Life Sci. 2015, vol. 72, p. 1–5. Disponible en: https://doi.org/10.1016/j.njas.2012.03.003spa
dc.relation.referencesKIM, Gyuri, et al. Statin use and the risk of hepatocellular carcinoma in patients at high risk: a nationwide nested case-control study. En: Journal of Hepatology. 2017. In press. Disponible en: https://doi.org/10.1016/j.jhep.2017.10.018spa
dc.relation.referencesKNOP, Doriv; YARDEN, Oded y HADAR, Yitzhak. The ligninolytic peroxidases in the genus Pleurotus: divergence in activities, expression and potencial applications. En: Applied Microbiology and Biotechnology. 2015, vol. 99, p. 1025-1038. Disponible en: https://doi.org/10.1007/s00253-014-6256-8spa
dc.relation.referencesKO, Yuan-Tih y LIN, Yu-Ling. 1,3-D-Glucan Quantification by a Fluorescence Microassay and Analysis of Its Distribution in Foods. En: Journal of agricultural and food chemistry, 2004, vol. 13, p. 3313–3318. Disponible en: https://doi.org/10.1021/jf0354085spa
dc.relation.referencesKOENIG, Steven, et al. Quantitative assay of β-(1,3)–β-(1,6)–glucans from fermentation broth using aniline blue. En: Carbohydrate Polymers. 2017, vol. 174, p. 57–64. Disponible en: https://doi.org/10.1016/j.carbpol.2017.06.047spa
dc.relation.referencesKOMURA, Dirce L., et al. Water-soluble polysaccharides from Pleurotus ostreatus var. florida mycelial biomass. En: International Journal of Biological Macromolecules. 2014, vol. 70, p. 354–359. Disponible en: https://doi.org/10.1016/j.ijbiomac.2014.06.007spa
dc.relation.referencesKONG, Fanli. Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from Pleurotus ostreatus. En: International Journal of Biological Macromolecules. 2014, vol. 69, p. 561–566. Disponible en: https://doi.org/10.1016/j.ijbiomac.2014.05.045spa
dc.relation.referencesKRINGS, Ulrich y BERGER, Ralf G. Dynamics of sterols and fatty acids during UV-B treatment of oyster mushroom. En: Food Chemistry. 2014, vol. 149, p. 10–14. Disponible en: https://doi.org/10.1016/j.foodchem.2013.10.064spa
dc.relation.referencesLAVI, Iris, et al. An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells. En: Cancer Letters. 2006, vol. 244, no. 1, p. 61–70. Disponible en: https://doi.org/10.1016/j.canlet.2005.12.007spa
dc.relation.referencesLEÓN, Orfelio G. y MONTERO, Ignacio. Cómo explicar el concepto de interacción sin estadística: análisis gráfico de todos los casos posibles en un diseño 2 x 2. En: Psicothema. 2001, vol. 13, no. 1, p. 159-165. Disponible en: http://www.redalyc.org/html/727/72713123/spa
dc.relation.referencesLIANG, Zeng-Chin, et al. Utilization of grass plants for cultivation of Pleurotus citrinopileatus. En: International Biodeterioration & Biodegradation. 2009, vol. 63, no. 4, p. 509–514. Disponible en: https://doi.org/10.1016/j.ibiod.2008.12.006spa
dc.relation.referencesLIMA, Marcos Dos Santos, et al. Phenolic compounds, organic acids and antioxidant activity of grape juices produced in industrial scale by different processes of maceration. En: Food Chemistry. 2015, vol. 188, p. 384–392. Disponible en: https://doi.org/10.1016/j.foodchem.2015.04.014spa
dc.relation.referencesLI, Jinyao, et al. Pleurotus ferulae water extract enhances the maturation and function of murine bone marrow-derived dendritic cells through TLR4 signaling pathway. En: Vaccine. 2015, vol. 33, p. 1923–33. Disponible en: https://doi.org/10.1016/j.vaccine.2015.02.063spa
dc.relation.referencesLI, Siqian y SHAH, Nagendra P. Effects of Pleurotus eryngii polysaccharides on bacterial growth, texture properties, proteolytic capacity, and angiotensin-I-converting enzymeinhibitory activities of fermented milk. En: J Dairy Sci. 2015, vol. 98, p. 2949 – 2961. Disponible en: https://doi.org/10.3168/jds.2014-9116spa
dc.relation.referencesLIU, Xiaonan, et al. Extraction and antioxidant activities of intracellular polysaccharide from Pleurotus sp. mycelium. En: International Journal of Biological Macromolecules. 2010, vol. 47, no. 2, p. 116–119. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2010.05.012spa
dc.relation.referencesLIU, Xinkui et al. Structure characterization and antitumor activity of a polysaccharide from the alkaline extract of king oyster mushroom. En: Carbohydrate Polymers. 2015, vol. 118, p. 101–106. Disponible en: https://doi.org/10.1016/j.carbpol.2014.10.058spa
dc.relation.referencesLLAURADÓ, Gabriel, et al. In-vitro antimicrobial activity and complement/macrophage stimulating effects of a hot-water extract from mycelium of the oyster mushroom Pleurotus sp. En: Innovative Food Science & Emerging Technologies. 2015, vol. 30, p. 177–183. Disponible en: https://doi.org/10.1016/j.ifset.2015.05.002spa
dc.relation.referencesLLAURADÓ, Gabriel, et al. Oral administration of an aqueous extract from the oyster mushroom Pleurotus ostreatus enhances the immunonutritional recovery of malnourished mice. En: Biomedicine and Pharmacotherapy. 2016, vol. 83, p. 1456– 1463. Disponible en: https://doi.org/10.1016/j.biopha.2016.08.067spa
dc.relation.referencesMACÁKOVÁ, Kateřina, et al. Tannins and their Influence on Health. En: UR-RAHMAN, Atta y CHOUDHARY, Muhammad Iqbal (Eds.), Recent Advances in Medicinal Chemistry Recent Advances in Medicinal Chemistry. Amsterdam: Bentham Science Publishers, 2014. p. 159–208. ISBN: 9780128039618spa
dc.relation.referencesMACHADO ROCHA, Leandro. Extracción de materias primas vegetales. En: PINZÓN, Roberto. Fundamentos de Tecnología de Productos Fitoterapéuticos. Bogotá D.C.: Área de Ciencia y Tecnología del Convenio Andrés Bello & Red Iberoamericana de Productos Fitofarmacéuticos (RIPROFITO) del subprograma X del CYTED, 2000. p. 61-70. ISBN 9586980014.spa
dc.relation.referencesMA, Gaoxing, et al. Purification, characterization and antitumor activity of polysaccharides from Pleurotus eryngii residue. En: Carbohydr Polym. 2014, vol. 114, p. 297–305. Disponible en: https://doi.org/10.1016/j.carbpol.2014.07.069spa
dc.relation.referencesMAITY, Kousik, et al. Structural characterization and study of immunoenhancing and antioxidant property of a novel polysaccharide isolated from the aqueous extract of a somatic hybrid mushroom of Pleurotus florida and Calocybe indica variety APK2. En: International Journal of Biological Macromolecules. 2011, Vol. 48, no. 2, p. 304–310. Disponible en: https://doi.org/10.1016/j.ijbiomac.2010.12.003spa
dc.relation.referencesMANZI, Pamela y PIZZOFERRATO, Laura. Beta-glucans in edible mushrooms. En: Food Chemistry. 2000, vol. 68, no. 3, p. 315–318. Disponible en: https://doi.org/10.1016/S0308-8146(99)00197-1spa
dc.relation.referencesMARTÍNEZ-RINCÓN, Leydi Johana. Colombia y Brasil, complejidad logística: ¿verdad o mito? EAFIT, 2016. p. 1. Disponible en: http://hdl.handle.net/10784/11244spa
dc.relation.referencesMARTÍNEZ-SÁNCHEZ, Angel y PÉREZ-PÉREZ, Manuela. R&D project efficiency management in the Spanish industry. En: International Journal of Project Management. 2002. vol. 20, no. 7, p. 545. Disponible en: https://doi.org/10.1016/S0263-7863(01)00024-2spa
dc.relation.referencesMASSADEH, Muhannad I.; FRAIJA, Abeer y FANDIB, Khalid. Effect of Carbon Sources on The Extracellular Lignocellulolytic Enzymetic System of Pleurotus Sajor-Caju. En: Jordan journal of Biological Science. 2010, vol. 3, no.2, p. 51–54. Disponible en: https://eis.hu.edu.jo/deanshipfiles/pub105086141.pdfspa
dc.relation.referencesMATTILA, Pirjo, et al. Basic composition and amino acid contents of mushrooms cultivated in Finland. En: Journal of Agricultural and Food Chemistry. 2002, vol. 50, no. 22, p. 6419–6422. Disponible en: https://doi.org/10.1021/jf020608mspa
dc.relation.referencesMAU, Jeng Leun, et al. Nonvolatile taste components of ear mushrooms. En: Journal of Agricultura and food chemistry. 1998, vol. 46, no.11 p. 4583 – 4586. Disponible en: https://10.1021/jf9805606spa
dc.relation.referencesMcCLEAR, Barry y GLENNIE-HOLMES, Malcolm. Enzymatic quantification of (1-3)(1-4)beta-D-Glucan in barley and malt. En: Journal of the Institute of Brewing. 1985, vol. 9, p. 285–295. Disponible en: https://doi.org/10.1002/j.2050-0416.1985.tb04345.xspa
dc.relation.referencesMILLER, Gail Lorenz. Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar. En: Analytical Chemistry. 1959, vol. 31, no. 3, p. 426–428. ISSN 0003-2700. Disponible en: https://doi.org/10.1021/ac60147a030spa
dc.relation.referencesMITRA, Amal K. y RODRÍGUEZ FERNANDEZ, Gisella. Latin America and the Caribbean: assessment of the advances in public health for the achievement of the Millennium Development Goals. En: Int J Environ Res Public Health. 2010, vol. 7, no. 5, p. 2238– 2255. Disponible en: https://doi.org/10.3390/ijerph7052238spa
dc.relation.referencesMITRA, Payel; KHATUA, Somanjana y ACHARYA, Krishnendu. Free radical scavenging and nos activation properties of water soluble crude polysaccharide from Pleurotus ostreatus. En: Asian Journal of Pharmaceutical and Clinical Research. 2013, vol. 6, no. 3, p. 67–70. Disponible en: http://www.ajpcr.com/Vol6Issue3/53.pdfspa
dc.relation.referencesMIZUNO, Masashi, et al. Contents of AntiTumor Polysaccharides in Certain Mushroomsand Their Immunomodulating Activities. En: Food Science and Technology Research2001, vol. 7, no. 1, p. 31–34. Disponible en: https://doi.org/10.3136/fstr.7.31spa
dc.relation.referencesMUÑOZ, Carlos. Cómo elaborar y asesorar una investigación de tesis. 2 ed. Ciudad de México: Pearson educación, 2011. 320 p. Disponible en: http://www.unamerida.com/documentos/bileidis/ElaborarTesis.pdfspa
dc.relation.referencesNASRI, Hamid, et al. New Concepts in Nutraceuticals as Alternative for Pharmaceuticals. En: Int J Prev Med. 2014, vol. 5, no. 12, p. 1487–1499. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336979/spa
dc.relation.referencesNATTOH, Godfrey, et al. Towards profiling differential distribution of bioactive molecules across four phenologies in Pleurotus djamor R22. En: Asian Pacific J Trop Dis. 2016, vol. 6, no. 6, p. 472–480. Disponible en: https://doi.org/10.1016/S2222-1808(16)6107xspa
dc.relation.referencesNITSCHKE, Jörg, et al. A new colorimetric method to quantify β-1,3-1,6-glucans in comparison with total β-1,3-glucans in edible mushrooms. En: Food chemistry. 2011 vol. 127, no. 2, p. 791–796. Disponible en: https://doi.org/10.1016/j.foodchem.2010.12.149spa
dc.relation.referencesNIKIFOROVA, Svetlana V.; POZDNYAKOVA, Natalia N. y TURKOVSKAYA, Olga V. Emulsifying agent production during PAHs degradation by the white rot fungus Pleurotus Ostreatus D1. En: Current Microbiology. 2009, vol. 58, no. 6, p. 554–558. https://doi.org/10.1007/s00284-009-9367-1spa
dc.relation.referencesNIKSIC, Miomir; KLAUS, Anita y ARGYROPOULOS, Dimitrios. Safety of foods based on mushrooms. En: PRAKASH, Vishweshwaraiah, et al. Regulating Safety of Traditional and Ethnic Foods. Waltham, Massachusetts: Academic Press, 2016. p. 423-425. ISBN 9780128006054.spa
dc.relation.referencesNNADIUKWU, Tochukwu Anthony; MONAGO, C. C. y CHUKU, L. C. Histological Effect of Combined Ethanol Extract of Moringa oleifera and Pleurotus ostreatus on the Pancreas of Alloxan-induced Diabetic Wistar Albino Rats. En: Journal of Applied Life Sciences International. 2016, vol. 5, no. 3, p. 1–8. Disponible en: https://doi.org/10.9734/JALSI/2016/26108spa
dc.relation.referencesORGANIZACIÓN DE LAS NACIONES UNIDAS (ONU). Objetivos de Desarrollo Sostenible. En: Cumbre Mundial sobre el Desarrollo Sostenible. Recuperado de http://www.un.org/sustainabledevelopment/es/summit/spa
dc.relation.referencesORGANIZACIÓN MUNDIAL DE LA SALUD (OMS). Informe mundial sobre el envejecimiento y la salud. Estados Unidos: OMS, 2015. 282 p. ISBN: 978-92-4069487 3. Disponible en: http://apps.who.int/iris/bitstream/10665/186466/1/9789240694873_spa.pdfspa
dc.relation.referencesORTIZ MORENO, Martha Lucía. Macromicetos en Zona Rural de Villavicencio. En: Rev Orinoquia. 2010, vol. 14, no. 2, p. 125 – 132. Disponible en: http://orinoquia.unillanos.edu.co/index.php/orinoquia/article/view/68/544spa
dc.relation.referencesPAHILA, Jade et al. Effects of ergothioneine-rich mushroom extracts on lipid oxidation and discoloration in salmon muscle stored at low temperatures. En: Food Chemistry. 2017, vol. 233, p. 273–281. Disponible en: https://doi.org/10.1016/j.foodchem.2017.04.130spa
dc.relation.referencesPALACIOS, Irene. Novel isolation of water-soluble polysaccharides from the fruiting bodies of Pleurotus ostreatus mushrooms. En: Carbohydrate Research. 2012, vol. 358, p. 72–77. Disponible en: https://doi.org/10.1016/j.carres.2012.06.016spa
dc.relation.referencesPALMIERI, Gianna, et al. Copper Induction of Laccase Isoenzymes in the Ligninolytic Fungus Pleurotus ostreatus. En: Applied And Environmental Microbiology. 2000, vol. 66, no 3, pp. 920–924. Disponible en: https://doi.org/10.1128/AEM.66.3.920-924.2000spa
dc.relation.referencesPALMER, Michelle y CHAGUTURU, Rathnam. Academia–pharma partnerships for novel drug discovery: essential or nice to have? En: Expert Opinion on Drug Discovery. 2017, p. 1. Disponible en: https://doi.org/10.1080/17460441.2017.1318124spa
dc.relation.referencesPAPASPYRIDI, Lefki-Maria, et al. Production of bioactive metabolites with pharmaceutical and nutraceutical interest by submerged fermentation of Pleurotus ostreatus in a batch stirred tank bioreactor. En: Procedia Food Science. 2011, vol. 1, no. 11, p. 1746–1752. Disponible en: https://doi.org/10.1016/j.profoo.2011.09.257spa
dc.relation.referencesPATRA, Sukesh, et al. A heteroglycan from the mycelia of Pleurotus ostreatus: Structure determination and study of antioxidant properties. En: Carbohydrate Research. 2013, vol. 368, p. 16–21. Disponible en: https://doi.org/10.1016/j.carres.2012.12.003spa
dc.relation.referencesPEDNEAULT, Karine, et al. Fatty acid profiles of polar and non-polar lipids of Pleurotus ostreatus and P. cornucopiae var. “citrinopileatus” grown at different temperaturas En: Mycological Research. 2007, vol. 111, no. 10, p. 1228–1234. Disponible en: https://doi.org/10.1016/j.mycres.2007.06.014spa
dc.relation.referencesPÉREZ-MARTÍNEZ, Ana S., et al. A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines. En: Vaccine. 2015, vol. 33, no. 1, p. 25–33. Disponible en: https://doi.org/10.1016/j.vaccine.2014.10.059spa
dc.relation.referencesPHAT, Chanvorleak; MOON, Bokyung y LEE, Chan. Evaluation of umami taste in mushroom extracts by chemical analysis, sensory evaluation, and an electronic tongue system. En: Food Chemistry. 2016, vol. 192, p. 1068–1077. Disponible en: https://doi.org/10.1016/j.foodchem.2015.07.113spa
dc.relation.referencesPINEDA INSUASTI, Julio Almicar. Desarrollo de una tecnología para la producción a pequeña escala de la biomasa del hongo ostra (Pleurotus ostreatus). Tesis de doctorado en Ciencias Técnicas. Universidad de Camagüey Ignacio Agramonte Loynaz. Facultad de Química. Departamento de Ingeniería Química. 203 p. Disponible en: http://repositorio.educacionsuperior.gob.ec/bitstream/28000/1586/1/TSENESCYT-00704.pdfspa
dc.relation.referencesPLEMENITAŠ, Ana, et al. Steroidogenesis in the fungus Pleurotus ostreatus. En: Comparative Biochemistry and Physiology – B: Biochemistry and Molecular Biology. 1999, vol. 123, no. 2, p. 175–179. Disponible en: https://doi.org/10.1016/S03050491(99)00053-Xspa
dc.relation.referencesRADZKI, Wojciech, et al. Effect of processing on the content and biological activity of polysaccharides from Pleurotus ostreatus mushroom. En: LWT - Food Science and Technology. 2016, vol. 66, p. 27–33. Disponible en: https://doi.org/10.1016/j.lwt.2015.10.016spa
dc.relation.referencesRAMESH, CH y PATTAR, Manohar G. Antimicrobial properties, antioxidant activity and bioactive compounds from six wild edible mushrooms of western ghats of Karnataka, India. En: Pharmacognosy Res. 2010, vol. 2, p. 107–112. Disponible en: https://doi.org/10.4103/0974-8490.62953spa
dc.relation.referencesRAMÍREZ-NIÑO, Miguel Ángel. Identificación y Cuantificación de carbohidratos totales. Guía de laboratorio de Química Agroindustrial. Villavicencio, Colombia: Universidad de Los Llanos, 2017. 4 p.spa
dc.relation.referencesRANA, Tanmoy, et al. Pleurotus florida lectin normalizes duration dependent hepatic oxidative stress responses caused by arsenic in rat. En: Experimental and Toxicologic Pathology. 2012, vol. 64, no. 7–8, p. 665–671. Disponible en: https://doi.org/10.1016/j.etp.2010.12.010spa
dc.relation.referencesREDDY, Gorla V., et al. Utilization of banana waste for the production of lignolytic and cellulolytic enzymes by solid substrate fermentation using two Pleurotus species (P. ostreatus and P. sajor-caju). En: Process Biochemistry. 2003, vol. 38, no. 10, pp. 1457–1462. Disponible en: https://doi.org/10.1016/S0032-9592(03)00025-6spa
dc.relation.referencesREN, Daoyuan, et al. Antioxidant and antitumor effects of polysaccharides from the fungus Pleurotus abalonus. En: Chem Biol Interact. 2015, vol. 237, p. 166–74. Disponible en: https://doi.org/10.1016/j.cbi.2015.06.017spa
dc.relation.referencesREN, Lu, et al. Antibacterial and antioxidant activities of aqueous extracts of eight edible mushrooms. En: Bioactive Carbohydrates and Dietary Fibre. 2014, vol. 3, no. 2, p. 41–51. Disponible en: https://doi.org/10.1016/j.bcdf.2014.01.003spa
dc.relation.referencesREN, Qilong, et al. Recent Advances in Separation of Bioactive Natural Products. En: Chinese Journal of Chemical Engineering. 2013, vol. 21, no. 9, p. 937–952. Disponible en: https://doi.org/10.1016/S1004-9541(13)60560-1spa
dc.relation.referencesRITCHER, Hermann Eberhard. Arzneitaschenbuch zur: Farmacopea Germanica. 5 ed. 178 p. Berlin: Springer Berlin Heidelberg, 1885. ISBN: 978-3-662-39333-8. Disponible en: https://doi.org/10.1007/978-3-662-40374-7spa
dc.relation.referencesROP, Otakar; MLCEK, Jiri y JURIKOVA, Tunde. Beta-glucans in higher fungi and their health effects. En: Nutrition Reviews. 2009, vol. 67, no. 11, p. 624–631. Disponible en: https://doi.org/10.1111/j.1753-4887.2009.00230.xspa
dc.relation.referencesSAFDAR, Muhammad N., et al. Extraction and quantification of polyphenols from kinnow (Citrus reticulate L.) peel using ultrasound and maceration techniques. En: Journal of Food and Drug Analysis. 2017, vol. 25, no. 3, p. 488-500. Disponible en: https://doi.org/10.1016/j.jfda.2016.07.010spa
dc.relation.referencesSALAS DE LA TORRE, N, et al. Deshidratación de hongos comestibles Pleurotus Ostreatus. En: Revista Peruana de Química Ingeniería Química 2003, vol 6, no. 1, p. 55-59. Disponible en: http://revistasinvestigacion.unmsm.edu.pe/index.php/quim/article/viewFile/4490/3576spa
dc.relation.referencesSANTOS-NEVES, Juliana C. et al. A novel branched αβ-glucan isolated from the basidiocarps of the edible mushroom Pleurotus florida. En: Carbohydrate Polymers. 2008, vol. 73, no. 2, p. 309–314. Disponible en: http://doi.org/10.1016/j.carbpol.2007.11.030spa
dc.relation.referencesSARANGI, Itisam, et al. Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans. En: International Immunopharmacology. 2006, vol. 6, no. 8, p. 1287–1297. Disponible en: https://doi.org/10.1016/j.intimp.2006.04.002spa
dc.relation.referencesSCHNEIDER, Inga, et al. Lipid lowering effects of oyster mushroom (Pleurotus ostreatus) in humans. En: Journal of Functional Foods. 2011, vol. 3, no. 1, p. 17–24. Disponible en: https://doi.org/10.1016/j.jff.2010.11.004spa
dc.relation.referencesSEMEDO, Magda C., KARMALI, Amín y FONSECA, Luís. A high throughput colorimetric assay of β-1,3-D-glucans by Congo red dye. En: Journal of microbiological methods. 2015, vol. 109, p. 140–148. Disponible en: https://doi.org/10.1016/j.mimet.2014.12.020spa
dc.relation.referencesSHAH, Z. A.; ASHRAFF, M. y ISHTIAQ, M. Comparative study on cultivation and yield performance of oyster mushroom (Pleurotus ostreatus) on the different substrates (wheat straw, leaves, sawdust). En: Pak J Nut. 2004, vol. 3, no. 3, p. 158–160. Disponible: https://doi.org/10.3923/pjn.2004.158.160spa
dc.relation.referencesSHI, Lei. Bioactivities, isolation and purification methods of polysaccharides from natural products: A review. En: International Journal of Biological Macromolecules. 2015, vol. 92, p. 37–48. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.06.100spa
dc.relation.referencesSINGLETON, Vernon L.; ORTHOFER, Rudolf y LAMUELA RAVENTÓS, Rosa M. Analysis of total phenols and other oxidation substrates and antioxidants by means of FolinCiocalteu reagent. En: Methods in Enzymology. 1999, vol. 299, p. 152–178. Disponible en: http://doi.org/10.1016/S0076-6879(99)99017-1spa
dc.relation.referencesSMIDERLE, Fhernanda R, et al. A 3-O-methylated mannogalactan from Pleurotus pulmonarius: Structure and antinociceptive effect. En: Phytochemistry. 2008, vol. 69, p.2731–2736. Disponible en: https://doi.org/10.1016/j.phytochem.2008.08.006spa
dc.relation.referencesSMIDERLE, Fhernanda R, et al. Anti-inflammatory and analgesic properties in a rodent model of a (1-->3), (1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius. En: European Journal of Pharmacology. 2008, vol. 597, no. 1–3, p. 86–91. Disponible en: https://doi.org/10.1016/j.ejphar.2008.08.028spa
dc.relation.referencesSMITH, JF; LÓPEZ MARTÍNEZ, de Alva, MARTÍNEZ CARRERA, Daniel. La producción comercial de hongos comestibles en Bolivia y Colombia. En: MARTÍNEZ-CARRERA, Daniel, et al. Hacia un Desarrollo sustentable de Producción-Consumo de los Hongos Comestibles y Medicinales en Latinoamérica: Avances y Perspectivas en el siglo XXI. Puebla: Red Latinoamericana de Hongos Comestibles y Medicinales-COLPOS-UNSCONACYT-AMC-UAEMUPAEP-IMINAP, 2010. p. 425–436. ISBN 970-9752-01-4.spa
dc.relation.referencesSMITH, Roger M. Before the injection - Modern methods of sample preparation for separation techniques. En: Journal of Chromatography A. 2003, vol. 1000, no. 1–2, p. 3–27. Disponible en: https://doi.org/10.1016/S0021-9673(03)00511-9spa
dc.relation.referencesSOOD, Ankita y GUPTA, Mahesh. Extraction process optimization for bioactive compounds in pomegranate peel. En: Food Bioscience. 2015, vol. 12, p. 100–106 Disponible en: https://doi.org/10.1016/j.fbio.2015.09.004spa
dc.relation.referencesSUÁREZ ARANGO, Carolina y NIETO, Ivonne Jeannette. Cultivo biotecnológico de macrohongos comestibles: una alternativa en la obtención de nutracéuticos. En: Revista Iberoamericana de Micología. 2013, vol. 30, no. 1, p. 1–8. Disponible en: https://doi.org/10.1016/j.riam.2012.03.011spa
dc.relation.referencesSULISTIANY, Henny, et al. Production of Fruiting Body and Antioxidant Activity of Wild Pleurotus. En: HAYATI Journal of Biosciences, 2016, vol. 23, no. 4, p. 191–195. Disponible en: https://doi.org/10.1016/J.HJB.2016.07.003spa
dc.relation.referencesSUN, Wu Ping, et al. Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. En: Clinical Nutrition. 2017, vol, 36, no. 4, p. 1136–1142. Disponible en: https://doi.org/10.1016/j.clnu.2016.07.016spa
dc.relation.referencesSUN, Yongxu y LIU, Jicheng. Purification, structure and immunobiological activity of a water-soluble polysaccharide from the fruiting body of Pleurotus ostreatus. En: Bioresource Technology. 2009, vol. 100, no. 2, p. 983–986. Disponible en: https://doi.org/10.1016/j.biortech.2008.06.036spa
dc.relation.referencesSUN, Yongxu, et al. Technology optimization for polysaccharides (POP) extraction from the fruiting bodies of Pleurotus ostreatus by Box-Behnken statistical design. En: Carbohydrate Polymers. 2010, vol. 80, no. 1, p. 242–247. Disponible en: https://doi.org/10.1016/j.carbpol.2009.11.018spa
dc.relation.referencesSZWENGIEl, Artur y STACHOWIAK, Bárbara. Deproteinization of water-soluble ß-glucan during acid extraction from fruiting bodies of Pleurotus ostreatus mushrooms. En: Carbohydrate Polymers. 2016, vol. 146, p. 310–319. Disponible en: https://doi.org/10.1016/j.carbpol.2016.03.015spa
dc.relation.referencesSYNYTSYA, Andriy, et al. Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: Structure and potential prebiotic activity. En: Carbohydrate Polymers. 2009, vol76, no.4, p. 548–556. Disponible en: http://doi.org/10.1016/j.carbpol.2008.11.021spa
dc.relation.referencesSYNYTSYA, Andriy y NOVÁK, Miroslav. Structural diversity of fungal glucans. En: Carbohydrate Polymers. 2013, vol. 92, no. 1, p. 792–809. Disponible en: https://doi.org/10.1016/j.carbpol.2012.09.077spa
dc.relation.referencesTAOFIQ, Oludemi, et al. Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics-A review. En: Industrial Crops and Products. 2016, vol. 90, p. 38–48. Disponible en: https://doi.org/10.1016/j.indcrop.2016.06.012spa
dc.relation.referencesTAOFIQ, Oludemi, et al. UV-irradiated mushrooms as a source of vitamin D2: A review. En: Trends in Food Science & Technology. 2017, vol. 70, p. 82-74. Disponible en: https://doi.org/10.1016/j.tifs.2017.10.008spa
dc.relation.referencesTEHRANI, Mohammad Hassan Houshdar, et al. Search for Proteins in the Liquid Extract of Edible Mushroom, Agaricusbisporus, and Studying their Antibacterial Effects. En: Iran J Pharm Res. 2012 Winter, vol 11, p. 145–150.spa
dc.relation.referencesTERRY, Paul, et al. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. En: Journal of the National Cancer Institute. 2001, vol. 93, no 7, pp. 525–533. Disponible en: https://doi.org/10.1093/jnci/93.7.525spa
dc.relation.referencesTHORPE, Edgar y THORPE, Showick. The Pearson General Knowledge Manual. India: Pearson, 2010. p. B27. ISBN 978-81-317-2790-4.spa
dc.relation.referencesTONG, Haibin, et al. Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus. En: Bioresource Technology. 2009, vol. 100, no. 4, p. 1682–1686. Disponible en: https://doi.org/10.1016/j.biortech.2008.09.004spa
dc.relation.referencesTORRES-CABRA, Eneida; HERNÁNDEZ-FERNÁNDEZ, Javier y PÉREZ-RUBIANO, Claudia. Cuantificación de proteínas totales en extractos crudos de cepas nativas de Bacillus thuringiensis aisladas de Boyacá y Cundinamarca. En: Conexión Agropecuaria JDC. 2013, vol. 3, no. 2, p. 37–43. Disponible en: http://www.revistasjdc.com/main/index.php/conexagro/article/view/314spa
dc.relation.referencesUNEKWU, Hamzah Rabiat, et al. Phytochemical screening and antioxidant activity of methanolic extract of selected wild edible Nigerian mushrooms. En: Asian Pacific Journal of Tropical Disease. 2014, vol. 4, no. S1. Disponible en: https://doi.org/10.1016/S2222-1808(14)60431-Xspa
dc.relation.referencesVALVERDE, Elizabeth y DOS SANTOS, Macedo. Extracción de materias primas vegetales. En: PINZÓN, Roberto. Fundamentos de Tecnología de Productos Fitoterapéuticos. Bogotá D.C.: Área de Ciencia y Tecnología del Convenio Andrés Bello & Red Iberoamericana de Productos Fitofarmacéuticos (RIPROFITO) del subprograma X del CYTED, 2000. p. 38. ISBN 9586980014.spa
dc.relation.referencesVALVERDE, María Elena; HERNÁNDEZ-PEREZ, Talía y PAREDES-LÓPEZ, Octavio. Edible mushrooms: improving human health and promoting quality life. En: Int J Microbiol. 2013, p. 1–14. Disponible en: https://doi.org/10.1155/2015/376387spa
dc.relation.referencesVAMANU, Emanuel. In vitro antioxidant and antimicrobial activities of two edible mushroom mycelia obtained in the presence of different nitrogen sources. En: Journal of Medicinal Food. 2013, vol. 16, no. 2, p. 155–166. Disponible en: https://doi.org/10.1089/jmf.2012.0030spa
dc.relation.referencesWANG, Hexiang; GAO, Jiquan y NG, T. B. A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. En: Biochemical and biophysical research communications. 2000. Vol. 275, nol. 3, p. 810– 816. Disponible en: https://doi.org/10.1006/bbrc.2000.3373spa
dc.relation.referencesWANG, Hexiang X. y NG, T. B. Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus mushroom with anti-human immunodeficiency virus, translation-inhibitory, and ribonuclease activities. En: Biochemical and biophysical research communications. 2000, vol. 276, no. 2, p. 587–593. Disponible en: https://doi.org/DOI 10.1006/bbrc.2000.3540spa
dc.relation.referencesWASSER, S. P. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. En: Appl Microbiol Biotechnol. 2002, Vol. 60, p. 258–274. Disponible en: https://doi.org/10.1007/s00253-002-1076-7spa
dc.relation.referencesWILDMAN, Robert E. C. y KELLEY, Mike. Nutraceutical and Functional Foods. En: Handbook of Nutraceuticals and Functional Foods. 2 ed. Boca Raton, Florida: Robert E. C. Wildman, 2007. p. 1–22. Disponible en: https://doi.org/10.1201/9781420006186spa
dc.relation.referencesXIA, Fengguo, et al. Antioxidant effects of a water-soluble proteoglycan isolated from the fruiting bodies of Pleurotus ostreatus. En: Journal of the Taiwan Institute of Chemical Engineers. 2011, vol. 42, no. 3, p. 402–407. Disponible en: https://doi.org/10.1016/j.jtice.2010.08.012spa
dc.relation.referencesXU, Xiaofei, et al. Bioactive proteins from mushrooms. En: Biotechnology Advances. 2011, vol. 29, no. 6, p. 667–674. Disponible en: https://doi.org/10.1016/j.biotechadv.2011.05.003spa
dc.relation.referencesYAN, Bingju; JING, Liying y WANG, Jun. A polysaccharide (PNPA) from Pleurotus nebrodensis offers cardiac protection against ischemia–reperfusion injury in rats. En: Carbohydr Polym. 2015, vol. 133, p. 1–7. Disponible en: https://doi.org/10.1016/j.carbpol.2015.06.076spa
dc.relation.referencesYANG, Qi, et al. Gastroprotective activities of a polysaccharide from the fruiting bodies of Pleurotus ostreatus in rats. En: International Journal of Biological Macromolecules. 2012, vol. 50, no. 5, p. 1224–1228. Disponible en: https://doi.org/10.1016/j.ijbiomac.2012.03.020spa
dc.relation.referencesYONG NAM, Sang y MOO LEE, Young. Pervaporation separation of methanol/methyl tbutyl ether through chitosan composite membrane modified with surfactants. En: Journal of Membrane Science. 1999, vol. 157, no. 1, p. 63–71. https://doi.org/10.1016/S0376-7388(98)00368-8spa
dc.relation.referencesYOSHIOKA, Yûko, et al. Antitumor polysaccharides from P. ostreatus (Fr.) quél.: Isolation and structure of a β-glucan. En: Carbohydrate Research. 1985, vol. 140, no. 1, p. 93– 100. Disponible en: https://doi.org/10.1016/0008-6215(85)85052-7spa
dc.relation.referencesYUSEF, Hasan M., THRELFALL, D. R. y GOODWIN, T. W. Some lipids of the oidia of Pleurotus ostreatus. En: Phytochemistry. 1965, vol. 4, no. 4, p. 559–562. Disponible en: https://doi.org/10.1016/S0031-9422(00)86216-0spa
dc.relation.referencesZEKOVIĆ, Djordje B, et al. Natural and Modified (1→3)-β-D-Glucans in Health Promotion and Disease Alleviation. En: Critical Reviews in Biotechnology. 2005, vol. 25, no. 4, p. 205–230. Disponible en: https://doi.org/10.1080/07388550500376166spa
dc.relation.referencesZERVAKIS, Georgios y BALIS, Constantinos. A pluralistic approach in the study of Pleurotus species with emphasis on compatibility and physiology of the European morphotaxa. En: Mycological Research. 1996, vol. 100, no. 6, p. 717–731. Disponible en: https://doi.org/10.1016/S0953-7562(96)80205-Xspa
dc.relation.referencesZHANG, Chen, et al. Antioxidant and hepatoprotective activities of intracellular polysaccharide from Pleurotus eryngii SI-04. En: Int J Biol Macromol. 2016, vol. 91, p. 568–577. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.05.104spa
dc.relation.referencesZHANG, Chengdong, et al. Edible fungus degrade bisphenol A with no harmful effect on its fatty acid composition. En: Ecotoxicology and Environmental Safety. 2015, vol. 118, p. 126–132. Disponible en: https://doi.org/10.1016/j.ecoenv.2015.04.020spa
dc.relation.referencesZHANG, Jie, et al. Antitumor polysaccharides from a Chinese mushroom, “yuhuangmo,” the fruiting body of Pleurotus citrinopileatus. En: Bioscience, biotechnology, and biochemistry. 1994, vol. 58, no. 7, p. 1195–1201. Disponible en: https://doi.org/10.1271/bbb.58.1195spa
dc.relation.referencesZHANG, Yan, et al. Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats. En: International Journal of Biological Macromolecules. 2016, vol. 83, p. 126–132. Disponible en: https://doi.org/10.1016/j.ijbiomac.2015.11.045spa
dc.relation.referencesZHANG, Yan, et al. Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer’s disease. En: International Journal of Biological Macromolecules. 2016, vol. 92, p. 935–941. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.08.008spa
dc.relation.referencesZHANG, Yan et al. Regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus on fat-emulsion-induced hyperlipidemia rats. En: International Journal of Biological Macromolecules. 2017, vol. 101, p. 107–116. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2017.03.084spa
dc.relation.referencesZHANG, Weimin, et al. Feeding with supplemental squalene enhances the productive performance in boars. En: Animal Reproduction Science. 2008, vol. 104, no. 2–4, p. 445–449. Disponible en: https://doi.org/10.1016/j.anireprosci.2007.08.003spa
dc.relation.referencesZHANG, Yunxia, et al. Characterization and in vitro antioxidant activities of polysaccharides from Pleurotus ostreatus. En: International Journal of Biological Macromolecules. 2012, vol. 51, no. 3, p. 259–265. Disponible en: https://doi.org/10.1016/j.ijbiomac.2012.05.003spa
dc.relation.referencesZHU, Fengmei, et al. Beta-glucans from edible and medicinal mushrooms: Characteristics, physicochemical and biological activities. En: Journal of Food Composition and Analysis. 2015, vol. 41, p. 165–173. Disponible en: https://doi.org/10.1016/j.jfca.2015.01.019spa
dc.rightsDerechos Reservados - Universidad de los Llanos, 2018spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.proposalMaceraciónspa
dc.subject.proposalExtracciónspa
dc.subject.proposalOptimizaciónspa
dc.subject.proposalPleurotusspa
dc.subject.proposalSustancias bioactivasspa
dc.subject.proposalMacerationeng
dc.subject.proposalExtractioneng
dc.subject.proposalOptimizationeng
dc.subject.proposalBioactive substanceseng
dc.titleEvaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámicaspa
dc.typeTrabajo de grado - Pregradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication

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