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Algunas consideraciones de epidemiología e inmunopatología de la peste porcina clásica

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dc.contributor.authorSalgado Ruíz, Jefersson Stiven
dc.contributor.authorJaramillo-Hernández, Dumar Alexander
dc.date.accessioned2023-11-08T13:56:51Z
dc.date.available2023-11-08T13:56:51Z
dc.date.issued2021
dc.descriptionIncluye figuras.spa
dc.description.abstractLa peste porcina clásica (PPC) es una enfermedad causada por un virus ARN de la familia Flaviviridae, genero Pestivirus conocido como Pestivirus C. En la actualidad se conoce su distribución mundial y es causante de grandes pérdidas económicas en las producciones porcícolas. Sus únicos reservorios naturales son el cerdo y el jabalí. El objetivo de esta revisión es presentar una actualización sobre algunos aspectos relevantes epidemiológicos e inmunopatológicos de la PPC. La PPC es una enfermedad de notificación obligatoria para Colombia y los animales persistentemente infectados son la clave para su diseminación y endemicidad. La infección por el virus de la PPC se caracteriza por coagulación intravascular diseminada, trombocitopenia e inmunosupresión, dependiendo en severidad por la virulencia de las distintas cepas. El virus tiene afinidad por monocitos/macrófagos y células endoteliales vasculares donde tiene la capacidad de inducir diferentes mecanismos celulares que le permiten proliferar y persistir en el animal como lo son: el estrés oxidativo al incrementar los niveles de especies reactivas de oxígeno que genera una disminución de la biodisponibilidad de óxido nítrico; la fisión mitocondrial que permite una supervivencia celular por la inhibición de la apoptosis; y la inmunosupresión debido a la depleción de linfocitos T y B creada por la piroptosis en función de la gasdermina-D en órganos linfoides periféricos que reduce la respuesta inmune humoral y celular. El entendimiento inmunopatológico desde la explicación molecular en la PPC es importante en el aporte conceptual del desarrollo de nuevas estrategias profilácticas y terapéuticas que permitan controlar/ erradicar esta enfermedad.spa
dc.description.abstractClassical swine fever (CSF) is a disease caused by RNA virus, Flaviviridae family, genus Pestivirus, known as Pestivirus C. At present its worldwide distribution is known and is the cause of great economic losses in pig production. Its only natural reservoirs are pigs and wild boar. The aim of this review is to present an update on some relevant epidemiological and immunopathological aspects of CSF. CSF is a notifiable disease for Colombia and persistently infected animals are the key to its spread and endemicity. CSF virus infection is characterized by disseminated intravascular coagulation, thrombocytopenia, and immunosuppression, depending on severity due to the virulence of the different strains. The virus has affinity for monocytes/macrophages and vascular endothelial cells where it has the ability to induce different cellular mechanisms that allow it to proliferate and persist in the animal, such as: oxidative stress by increasing the levels of reactive oxygen species that generates a decrease of the bioavailability of nitric oxide; mitochondrial fission that allows cell survival by inhibiting apoptosis; and immunosuppression due to the depletion of T and B lymphocytes created by pyroptosis as a function of gasdermin-D in peripheral lymphoid organs that reduces the humoral and cellular immune response. The immunopathological understanding from the molecular explanation in CSF is important in the conceptual contribution of the development of new prophylactic and therapeutic strategies that allow to control/eradicate this disease. Keywords: Communicable diseases; immunology; oxidative stress; pyroptosis; virology (Source:DeCS).eng
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dc.identifier.citationSalgado-Ruíz, J. S. y Jaramillo-Hernández, D. A. (2021). Algunas consideraciones de epidemiología e inmunopatología de la peste porcina clásica. Revista MVZ Córdoba,27(1).spa
dc.identifier.eissn2361spa
dc.identifier.instnameUniversidad de los Llanosspa
dc.identifier.issn0122-0268spa
dc.identifier.reponameRepositorio Universidad de los Llanosspa
dc.identifier.repourlhttps://repositorio.unillanos.edu.co/spa
dc.identifier.urihttps://repositorio.unillanos.edu.co/handle/001/3124
dc.language.isospaspa
dc.publisherUniversidad de Los Llanosspa
dc.publisher.placeVillavicenciospa
dc.relation.citationissue1spa
dc.relation.citationvolumeVol. 27spa
dc.relation.indexedN/Aspa
dc.relation.ispartofjournalRevista MVZ Córdobaspa
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dc.rightsDerechos Reservados - Universidad de Los Llanos, 2021spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.sourcehttps://doi.org/10.21897/rmvz.2361spa
dc.subject.armarcPeste porcina
dc.subject.proposalEnfermedad transmisiblespa
dc.subject.proposalInmunologíaspa
dc.subject.proposalEstrés oxidativospa
dc.subject.proposalPiroptosisspa
dc.subject.proposalCommunicable diseaseseng
dc.subject.proposalImmunologyeng
dc.subject.proposalOxidative stresseng
dc.subject.proposalPyroptosiseng
dc.titleAlgunas consideraciones de epidemiología e inmunopatología de la peste porcina clásicaspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
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dc.type.contentTextspa
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dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
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