Publicación: Caracterización genética del genoma completo de una cepa del virus Chikungunya circulante en Brasil
dc.contributor.author | Villarreal Julio, Rafael Guillermo | spa |
dc.contributor.author | Yepes-Blandón, Jonny Andrés | spa |
dc.date.accessioned | 2023-07-04T00:00:00Z | |
dc.date.accessioned | 2024-07-25T18:15:22Z | |
dc.date.available | 2023-07-04T00:00:00Z | |
dc.date.available | 2024-07-25T18:15:22Z | |
dc.date.issued | 2023-07-04 | |
dc.description.abstract | El virus Chikungunya (CHIKV) es un virus de ARN monocatenario de sentido positivo que pertenece al género Alphavirus de la familia Togaviridae. Se transmite principalmente por mosquitos Aedes aegypti y albopictus. Su genoma codifica cuatro proteínas no estructurales (NSP 1-4) y tres proteínas estructurales (C, E1 y E2). Se han identificado cuatro linajes de este virus que son los linajes de África occidental, África oriental, central y sudafricana (ECSA), asiático (AL) y del océano Índico (IOL).1. CHIKV es un arbovirus endémico circulante en 51 países de las Américas. Las manifestaciones clínicas que se le atribuyen son; fiebre alta, erupción cutánea, mialgia y episodios de artralgia, que en consecuencia provocan dolor crónico y discapacidad, especialmente en articulaciones. La secuenciación del genoma completo del virus del Chikungunya es esencial para comprender su biología, evolución y propagación, y para desarrollar estrategias efectivas de prevención, diagnóstico y tratamiento. Esta información es fundamental para combatir la enfermedad y minimizar su impacto en la salud pública. Por esas razones se secuenció el genoma completo del virus Chikungunya br33, identificada en la ciudad nororiental de Recife, en el estado de Pernambuco, Brasil. El genoma tiene un tamaño de 11601 nucleótidos y fragmentos que codifican para dos poliproteínas.Se realizó un análisis filogénico que indica que la reciente cepa brasileña del CHIKV pertenece al linaje del este, centro y sur de África (ECSA). Dicha identificación filogenética es importante porque este genotipo en particular ha sido asociado a mayor daño y severidad clínica.Hasta 2016, el virus CHIKV estaba asociadas directamente a viajes y la transmisión era limitada. Posteriormente se produjo el brote más grande en el estado asociado con la introducción de un nuevo linaje ECSA como el indetificado en este estudio. Es muy probable que se produzcan nuevos brotes de CHIKV en un futuro cercano debido a la abundancia de vectores competentes en brazil y a una población susceptible, exponiendo a más de 11 millones de habitantes a un riesgo de infección cada vez mayor. | spa |
dc.description.abstract | The Chikungunya virus (CHIKV) is a single-stranded positive-sense RNA virus that belongs to the Alphavirus genus of the Togaviridae family. It is primarily transmitted by Aedes aegypti and albopictus mosquitoes. Its genome encodes four non-structural proteins (NSP 1-4) and three structural proteins (C, E1, and E2). Four lineages of this virus have been identified, namely the West African, East African, Central and South African (ECSA), Asian (AL), and Indian Ocean Lineages (IOL). CHIKV is an endemic arbovirus circulating in 51 countries in the Americas. Clinical manifestations attributed to it include high fever, rash, myalgia, and episodes of arthralgia, which subsequently lead to chronic pain and disability, especially in the joints. Sequencing the complete genome of the Chikungunya virus is essential to understand its biology, evolution, and spread and to develop effective strategies for prevention, diagnosis, and treatment. This information is crucial for combating the disease and minimizing its impact on public health. For these reasons, the complete genome of the Chikungunya virus strain br33, identified in the northeastern city of Recife, in the state of Pernambuco, Brazil, was sequenced. The genome has a size of 11,601 nucleotides and contains coding regions for two polyproteins. A phylogenetic analysis indicates that the recent Brazilian strain of CHIKV belongs to the East, Central, and South African lineage (ECSA). This phylogenetic identification is important because this particular genotype has been associated with greater damage and clinical severity. Until 2016, the CHIKV virus was directly associated with travel, and its transmission was limited. Subsequently, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage, as identified in this study. It is highly likely that new CHIKV outbreaks will occur in the near future due to the abundance of competent vectors in Brazil and a susceptible population, exposing more than 11 million inhabitants to an increasing risk of infection. | eng |
dc.format.mimetype | application/pdf | eng |
dc.identifier.doi | 10.22579/20112629.789 | |
dc.identifier.eissn | 2011-2629 | |
dc.identifier.issn | 0121-3709 | |
dc.identifier.uri | https://repositorio.unillanos.edu.co/handle/001/4050 | |
dc.identifier.url | https://doi.org/10.22579/20112629.789 | |
dc.language.iso | eng | eng |
dc.publisher | Universidad de los Llanos | spa |
dc.relation.bitstream | https://orinoquia.unillanos.edu.co/index.php/orinoquia/article/download/789/1312 | |
dc.relation.citationendpage | 789 | |
dc.relation.citationissue | 2 | spa |
dc.relation.citationvolume | 27 | spa |
dc.relation.ispartofjournal | Orinoquia | spa |
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dc.rights | Orinoquia - 2023 | eng |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | eng |
dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | eng |
dc.rights.creativecommons | Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. | eng |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | eng |
dc.source | https://orinoquia.unillanos.edu.co/index.php/orinoquia/article/view/789 | eng |
dc.subject | Emerging alphaviruses | eng |
dc.subject | Chikungunya fever | eng |
dc.subject | Genome | eng |
dc.subject | genoma sequencing | eng |
dc.subject | Vírus alfa emergentes | eng |
dc.subject | febre de Chikungunya | eng |
dc.subject | genoma | eng |
dc.subject | sequenciamento | eng |
dc.subject | Alfavirus emergentes | spa |
dc.subject | Fiebre Chikungunya | spa |
dc.subject | Genoma | spa |
dc.subject | Secuenciación | spa |
dc.title | Caracterización genética del genoma completo de una cepa del virus Chikungunya circulante en Brasil | spa |
dc.title.translated | Genetic characterization of the complete genome of a strain of Chikungunya virus circulating in Brazil | eng |
dc.type | Artículo de revista | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | eng |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | eng |
dc.type.content | Text | eng |
dc.type.driver | info:eu-repo/semantics/article | eng |
dc.type.local | Journal article | eng |
dc.type.version | info:eu-repo/semantics/publishedVersion | eng |
dspace.entity.type | Publication | eng |