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Patogénesis de la paratuberculosis y la enfermedad de Crohn ¿existe vínculo etiológico?

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dc.contributor.advisorGonzález Paya, Gustavo
dc.contributor.authorPerdomo Bedoya, Miguel Ángel
dc.contributor.corporatenameUniversidad de los Llanosspa
dc.date.accessioned2023-11-28T20:30:15Z
dc.date.available2023-11-28T20:30:15Z
dc.date.issued2019
dc.descriptionIncluye figuras y tablas.spa
dc.description.abstractEl Mycobacterium avium subespecie paratuberculosis (MAP) es el agente causal de la enfermedad de Johne en rumiantes, una enteritis granulomatosa crónica y se ha sugerido desde hace más de un siglo el posible vínculo zoonótico del MAP como agente etiologico de la Enfermedad de Crohn (EC) en humanos, debido, a las similitudes histopatológicas de las dos enfermedades, sin embargo, aún no se ha establecido un vínculo etiológico del MAP en la patogénesis de la Enfermedad de Crohn, con una etiología que puede ser multifactorial, las complicadas pruebas disganosticas y la dificultad del aislamiento por cultivo del MAP no ha permitido dilucidar la asociación causal del MAP y humanos con Enfermedad de Crohn. Buscando dar respuesta a la pregunta ¿Existe un vínculo etiológico entre la paratuberculosis y la Enfermedad de Crohn?, se realizó una investigación documental crítica y actualizada de las evidencias científicas expuestas en los últimos cinco años sobre lo hallazgos más representativos del posible vínculo de MAP en la etiopatogenia de la Enfermedad de Crohn, se encontró en algúnos reportes de casos e investigaciones realizadas en este periodo de tiempo la presencia de MAP en tejidos de pacientes con EC mediante distintas técnicas diagnósticas confirmando la posibilidad que el MAP es un patógeno zoonótico.spa
dc.description.abstractMycobacterium avium subspecies paratuberculosis (MAP) is the causal agent of Johne's disease in ruminants, a chronic granulomatous enteritis, and the possible zoonotic link of MAP as an etiological agent of Crohn's disease (CD) has been suggested for more than a century. ) in humans, due to the histopathological similarities of the two diseases, however, an etiological link of MAP in the pathogenesis of Crohn's Disease has not yet been established, with an etiology that may be multifactorial, The complicated diagnostic tests and the difficulty of isolating MAP by culture have not allowed us to elucidate the causal association of MAP and humans with Crohn's Disease. Seeking to answer the question: Is there an etiological link between paratuberculosis and Crohn's Disease?, a critical and updated documentary investigation of the scientific evidence presented in the last five years was carried out on the most recent findings. representative of the possible link of MAP in the etiopathogenesis of Crohn's Disease, the presence of MAP in tissues of patients with CD was found in some case reports and investigations carried out in this period of time using different techniques. diagnostics confirming the possibility that MAP is a zoonotic pathogen.eng
dc.description.degreelevelPregradospa
dc.description.degreenameMedico(a) Veterinario(a) Zootecnistaspa
dc.description.programMedicina Veterinaria y Zootecniaspa
dc.description.tableofcontentsResumen. -- Introducción. -- justificación. -- Objetivos. -- General. -- Específicos. -- Marco teórico. -- Generalidades. -- Características del mycobacterium avium subespecie paratuberculosis. -- Clasificación taxonómica. -- Características morfológicas. -- Características bioquímicas. -- Características microbiológicas. -- Genotipificación. -- Factores de virulencia mycobacterium avium subespecie paratuberculosis. -- Vías de transmisión del mycobacterium avium subespecie Paratuberculosis. -- Transmisión horizontal (fecal-oral . -- Transmisión horizontal (contacto sexual). -- Transmisión vertical. -- Transmisión vertical (fetal). -- Fisiopatología de la paratuberculosis. -- Etapas de la infeccion por mycobacterium avium subespecie Paratuberculosis. -- Respuesta inflamatoria. -- Mecanismo de supervivencia intracelular del mycobacterium . -- Avium subespecie paratuberculosis. -- Fisiopatología de la enfermedad de crohn. -- 4.5.1. Factores genéticos. -- Factores inmunológicos. -- Alteración de la microbiota intestinal. -- Alteración del tejido adiposo. -- Signos clínicos. -- Signos clínicos de la paratuberculosis. -- Signos clínicos de la enfermedad de crohn. -- Lesiones macroscópicas. -- Lesiones macroscópicas de la paratuberculosis. -- Lesiones macroscopicas de la enfermedad de crohn. -- Lesiones microscópicas. -- Lesiones microscópicas de la paratuberculosis. -- Lesiones microscópicas de la enfermedad de Crohn. -- Epidemiología. -- Situación mundial de la paratuberculosis. -- Situación de la paratuberculosis en Colombia. -- Control de la paratuberculosis. -- Ensayos diagnósticos en los últimos 5 años (2015-2019). -- Cronología de la enfermedad de Johne. -- Discusión. -- Conclusiones. -- Recomendaciones. -- Referencia bibliografía.spa
dc.format.extent109 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationPerdomo Bedoya, M. (2019). Patogénesis de la paratuberculosis y la enfermedad de Crohn ¿existe vínculo etiológico? [Trabajo de grado, Universidad de los Llanos]. Repositorio digital Universidad de los Llanos.spa
dc.identifier.instnameUniversidad de los Llanosspa
dc.identifier.reponameRepositorio digital Universidad de los Llanosspa
dc.identifier.repourlhttps://repositorio.unillanos.edu.co/spa
dc.identifier.urihttps://repositorio.unillanos.edu.co/handle/001/3244
dc.language.isospaspa
dc.publisherUniversidad de los Llanosspa
dc.publisher.facultyFacultad de Ciencias Agropecuarias y Recursos Naturalesspa
dc.publisher.placeVillavicenciospa
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dc.rightsDerechos Reservados - Universidad de los Llanos 2019spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.armarcEnfermedades bacterianas
dc.subject.armarcInfecciones estreptocócicas
dc.titlePatogénesis de la paratuberculosis y la enfermedad de Crohn ¿existe vínculo etiológico?spa
dc.typeTrabajo de grado - Pregradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.redcolhttps://purl.org/redcol/resource_type/TPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
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